2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P5786
    Heteropodatoxin-1
    Heteropodatoxin-1 (HpTx1), a spider peptide toxin, is a Kv4.2 current inhibitor. Heteropodatoxin-1 also inhibits Nav1.7 and activates Nav1.9 but does not affect Nav1.8.
    Heteropodatoxin-1
  • HY-P5788
    Hemitoxin
    Hemitoxin, a scorpion-venom peptide, is a K+ channel blocker. Hemitoxin blocks rat Kv1.1, Kv1.2 and Kv1.3 channels expressed in Xenopus oocytes with IC50 values of 13 nM, 16 nM and 2 nM, respectively.
    Hemitoxin
  • HY-P5790
    μ-TRTX-Hd1a
    μ-TRTX-Hd1a, a spider venom, is a selective NaV 1.7 inhibitor. μ-TRTX-Hd1a is a gating modifier that inhibits human NaV 1.7 by interacting with the S3b-S4 paddle motif in channel domain II.
    μ-TRTX-Hd1a
  • HY-P5791
    Haplotoxin-2
    Haplotoxin-2 is a peptide toxin that can be isolated from Haplopelma lividum.
    Haplotoxin-2
  • HY-P5793
    GTx1-15
    GTx1-15 is an inhibitor cystine knot (ICK) peptide that inhibits the voltage-dependent calcium channel Cav3.1 and the voltage-dependent sodium channels Nav1.3 and Nav1.7.
    GTx1-15
  • HY-P5795
    GsAF-I
    GsAF-I is a potent Nav and hERG1 channels blocker with IC50s of 0.36, 0.6, 1.28, 0.33, 1.2, 0.04 and 4.8 μM against Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, Nav1.7 and hERG1, respectively.
    GsAF-I
  • HY-P5796
    FS-2
    FS-2 is a potent and specific L-type CaV channel inhibitor. FS-2 inhibits high K+ or glucose induced L-type Ca2+ influx in RIN beta cells.
    FS-2
  • HY-P5798
    Fasciculin-I
    Fasciculin-I is isolated from the mambas venom. Fasciculin-I exerts its toxic effects by inhibiting acetylcholinesterase (AChE). Fasciculin-I blocks α-neurotoxins of nicotinic acetylcholine receptors and cardiac toxins that interact with cell membranes .
    Fasciculin-I
  • HY-P5800
    Phlo1b
    Phlo1b (μ-TrTx-Phlo1b) is a peptide toxin contains 35-amino acid residues. Phlo1b is a selective Nav1.7 inhibitor. Phlo1b has a weak inhibitory effect on Nav1.2 and Nav1.5.
    Phlo1b
  • HY-P5801
    Phlo1a
    Phlo1a (μ-TrTx-Phlo1a) is a peptide toxin contains 35-amino acid residues. Phlo1b is a selective Nav1.7 inhibitor. Phlo1a has a weak inhibitory effect on Nav1.2 and Nav1.5.
    Phlo1a
  • HY-P5806
    Ergtoxin-1 304436-85-9
    Ergtoxin-1 is a potassium channel blocker. Ergtoxin-1 is isolated from the venom of the Mexican scorpion Centruroides noxius. Ergtoxin 1 can block ERG-K+ channels in nerve, heart and endocrine cells.
    Ergtoxin-1
  • HY-P5807
    Cn2 toxin
    Cn2 toxin is aβ- toxoins. Cn2 toxin can bind to the voltage sensing domain of voltage gated sodium channels (Nav) .
    Cn2 toxin
  • HY-P5809
    Pe1b
    Pe1b (μ-TrTx-Pe1b) is a selective Nav1.7 inhibitor with an IC50 of 167 nM.
    Pe1b
  • HY-P5810
    Ceratotoxin-2 880885-98-3
    Ceratotoxin-2 (CcoTx2) is a voltage-gated sodium channel blocker with IC50s of 8 nM and 88 nM against Nav1.2/β1 and Nav1.3/β1, respectively.
    Ceratotoxin-2
  • HY-P5811
    Ceratotoxin-1
    Ceratotoxin-1 (CcoTx1), a peptide toxin, is an voltage-gated sodium channel subtypes inhibitor. Ceratotoxin-1 inhibits Nav1.1/β1, Nav1.2/β1, Nav1.4/β1, and Nav1.5/β1 with IC50 of 523 nM, 3 nM, 888 nM, and 323 nM, respectively. Ceratotoxin-1 also inhibits Nav1.8/β1.
    Ceratotoxin-1
  • HY-P5813
    Cd1a
    Cd1a is a β-toxin derived from the African spider Ceratogyrus darlingi. Cd1a can regulate calcium ion channels. Cd1a inhibits human calcium ion channels (Cav2.2)(IC502.6 μM) and mouse sodium ion channels (Nav1.7). Cd1a can be used in the development of peripheral pain treatment drugs .
    Cd1a
  • HY-P5816
    BmK-M1
    BmK-M1 is a scorpion toxin, and is composed of 64 amino acids cross-linked by four disulfide bridges. BmK-M1 inhibits Na+ channel and can be considered both as a cardiotoxin and a neurotoxin.
    BmK-M1
  • HY-P5818
    BDS-II
    BDS-II is a peptide toxin, and is composed of 43 amino acids. BDS-II is a selective Kv3.4 channel inhibitor.
    BDS-II
  • HY-P5823
    Azemiopsin 1391936-86-9
    Azemiopsin is a potent nicotinic acetylcholine receptor (nAChR) inhibitor with IC50s of 0.18 μM and 22 μM against T. californica nAChR and human α7 nAChR, respectively. Azemiopsin blocks acetylcholine-induced currents in Xenopus oocytes heterologously expressing human muscle-type nAChR.
    Azemiopsin
  • HY-P5824
    Anthopleurin-C
    Anthopleurin-C (APE 2-1) is a cardiotonic polypeptide that shows a powerful positive inotropic effect.
    Anthopleurin-C
Cat. No. Product Name / Synonyms Application Reactivity